| The Influence of
Micronutrition on Survival and
Quality of Life When Combined with Standard Therapy Protocols for Aggressive and Advanced Malignancies H. R. McDaniel, M.D.
Medical Director, Fisher Institute for Medical Research, Grand Prairie,
Texas In 1985 pilot studies
using the bioactive extract from aloe leaf gel, polymannose (APM) was
used in AIDS patients. Elevations of CD4 lymphocytes and
reductions in HIV-1 viral load was noted (McDaniel 1988) in parallel
with remissions of Kaposis sarcoma and lymphoma tumor mass. This
led to adding APM to the diet of advanced and hospice cancer patients
that had failed standard treatment protocols. Tumor mass reduction
and increase in quality of life was noted in 40 to 50% of patients
(McDaniel 1990). The working hypothesis was that innate immune
mechanisms that counter viral infections that integrate nucleic acid
sequences into the genome have similar activity to detect and destroy
cells with oncogene mutations. It was recognized that 9
molecules of manose-6PO4 required in the
endoplasmic reticulum (Kornfeld 1985) to start synthesis of antiviral
and anti-malignant cell cytokines. Michaelis-Menten substrate supply
dynamics predict that synthesis of cytokines will be increased if the
APM supply is increased (Murray 1990). In mixed-leukocyte cultures
a dose-response gradient by ELISA assay for increased synthesis of
γ-interferon, IL-1, IL-2, IL-6, and TNF was noted (Marshall 1993).
A 4-hour incubation of cells from the previous experiment (NK assay)
demonstrated a rising lysis gradient released by Cr 59
laden target malignant cells and herpes II-seeded cells that was
proportional to the supply of APM provided leukocytes (Marshall 1993).
Murine sarcoma 100% resistant to therapeutic modalities responded to a
single APM injection by a 40% eradication of tumor cells.
Bi-weekly administration raised survival to 65% and combined with
surgical removal survival rose to 85-90% (Busbee 1996). A report of 100
miscellaneous anecdotal cases of various types of malignancy in which
micronutrients were provided with standard protocols claimed an increase
in quality of life during treatment, enhanced tumor mass reduction,
protection of bone marrow and stem cells and responses in cell types
resistant to standard therapy (Hyland 1999). The current report is
a case series survey of human malignancies associated with short
survivals that combined micronutrient dietary supplementation with
standard therapy for malignancies. It is prepared for a
“Best Case Series” Center for Complementary and Alternative Medicine
cooperative NCI grant. For review will be 6 cases of
pancreatic cancer with metastasis that have an average survival of 82
months survival with a range of (48 -140_months with 3 living; 4
astrocytoma Grade III-IV average survival of 73 months, ranging (20-117)
with two living; 5 sarcomas averaging 94months survival ranging 87-131
with 5 living; miscellaneous advanced recurrent malignancies with
initial hospice status with an average survival of 178 months ranging
(94-263) months survival. While undergoing standard
radiation or chemo therapy there was a significant improvement in
quality of life as indicated by less fatigue, nausea, vomiting, bone
marrow toxicity, mucositis, loss of appetite, weight loss, and hair
loss. It is concluded that formal prospective studies with and
without micronutrient dietary supplementation combined with standard
treatment protocols for a comparison of quality of life, tumor mass
impact, and survival is warranted. More details including
patient scans can be obtained in the Best Case Cancer Syllabus available
at Fisher Institute Helen@fisherinstitute.org
or (972) 660-1733 An alternative is the two DVDs on cancer availavle duplipack@aol.com 888-443-1979
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| Interview Work
Sheet for Best Case Series:
Diagnostic Group________________
Patient Name_____________________ Date of Birth__________ Contact
information_________________ Permission to obtain records received_____ App. Date of first symptoms
that led to discovering malignancy_____________ Date diagnosis of malignancy was made_____________ How was diagnosis established Where and who did the procedure_______________ Treatments received: Date
and place of surgery_______________________ Tumor
said to be completely removed______________________ Date of reocurrance_______________ How determined___________ Where__________ Tumor
metastatic to Lungs__, liver_, brain__, bone__, other___________ Additional
treatment_____________________ Date Micronutrients started:_______ Standard treatment Chemo___Radiation___
Did you have previous treatment without micronutrients?___ Did you have treatment with Micronutrients?____________ Was there a difference?___
Explain difference Any tumor now detected___ Fatigue endurance Weight before tumor ____ lowest wt_____. current weight____ Current Status? This date______ Years since diagnosis___ All evidence of tumor gone? ____ Tumor markers normal? Percent of quality of life for age____? Working?___
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