Can this fatigue lead to paralysis?   


Fatigue - Prostate Cancer - Paralysis
definition:
extramedullary hematopoiesis: red blood cell production outside the vertebrae. Red blood cells are derived from the stem cells in the bone marrow throughout the body. When individuals become severely anemic, there is not enough space in the ctive bone marrow to produce hemoglobin, and the body begins to make blood outside the bone marrow: in the spleen, liver, and sometimes outside the vertebrae, which can compress the spinal cord, leading to paralysis
I heard of paralysis happening to a painter (who died this past 2003 as a young man about 44). He was being seen for prostate cancer, and he had pain in his back & bones, but didn't get a diagnosis for that. Then he became paralyzed ... due to?

His family (after his death) said that he had all of the symptoms of this chemical exposure, 2-butoxyethanol - (& of course he was exposed to the chemical) but he didn't get an accurate diagnosis - they didn't know what was happening with his bones. Since there is a red blood cell anemia, I was wondering if the above definition was part of what is happening to these .... (either from very extreme, serious exposure to too much of the chemical even in a brief exposure, or in many mini exposures over a long period of time)? 

shares his family:  

"The correct diagnosis was that his red blood cell where reproducing outside of the spine causing spinal cord compression.. Once this happens you have a 72 hour slide period to have surgery to release the compression or a bone marrow transplant. Maurice missed this 72 hour period by two weeks. Because other oncologist did not do his job well. Maurice was in Little co. of Mary Hospital and this doctor came in the room and pressed his hand on his back and said no pain no cancer on back. I responded how could he feel pain he is on morphine. The Dr. rudely turned to me and said he has a few small cancer spots in his tummy and walked away"  2-21-04

The chemical that affects painters & many others is 2-butoxyethanol (a pesticide, solvent, poison). The first thing people notice who are affected by it is all-the-time fatigue (red blood cell damage) that no rest helps - No energy; then depression all the time, personality changes to very grouchy, 'grumpy' - Extreme Irritability, Loose temper easily, Short term memory loss, Difficulty concentrating, Suicidal Tendencies, (many assorted central nervous system diagnosis) ... endocrine disruption to pituitary? to thyroid? to blood pressure? to blood sugar? to reproductive organs? to adrenal glands? This chemical, also known as ethylene glycol monobuytl ether, is known to cause hemolytic anemia, but I have wondered why it is so hard to find. The red blood cell counts come in borderline normal.

Then I realized that it takes awhile for the blood system to get so bad that it shows up. The retic ratio should indicate if there aren't enough mature red blood cells, shouldn't it?

 

definition:
One definition of Hemolytic anemia: At the end of their normal life span (about 120 days), RBCs are removed by components of the mononuclear phagocyte system, principally in the spleen, where Hb catabolism takes place. The essential feature of hemolysis is a shortened RBC life span; hemolytic anemia results when bone marrow production can no longer compensate for the shortened RBC survival.
These are symptoms of hemolytic anemia
  • Chills
  • Fatigue
  • Pale color
  • Shortness of breath
  • Rapid heart rate
  • Yellow skin color (jaundice)
  • Dark urine (indicative of blood in urine - never dismiss this! Stop exposure immediately!)
  • Enlarged spleen
quote:
Butoxyethanol, 2- (CICADS)
Concise International Chemical Assessment Document 10 2-Butoxyethanol This report contains the collective views of an international group of...

This & more

Other definitions for those who may need to check your blood in particular ways.
What ways? (Now with links to definitions)

Back up definitions here:

 

definition:


reticulocyte: a young red cell (erythrocyte) released by the bone marrow that contains no nucleus but has residual RNA; normally composes about 1% of circulating blood cells. The reticulocyte count is increased in hemolytic anemia.
definition:
Granulocytosis: an increase in the number of blood granulocytes - compare LYMPHOCYTOSIS, MONOCYTOSIS Causes of reactive granulocytosis include: Infection: Inflammatory ... marrow suppression.  
What are the major pathophysiologic mechanisms for granulocytosis?
Elevation of the granulocyte count may result from a primary bone marrow disorder resulting in autonomous proliferation of cells or it may be a secondary response to an underlying condition. There are a few, rare syndromes associated with granulocytosis without an underlying cause.
definition:
erythrocytosis: an increase in the number of red cells in the blood, esp. in response to a stimulus such as anemia. Erythropenia (eh-REETH-ro-PEA-nee-uh) The condition of having abnormally low numbers of red blood cells
definition:
leukocytes: all the white cells including: neutrophils, lymphocytes, eosinophils, basophils, and monocytes. eukocytosis: any condition in which the number of leukocytes or white cells in the circulating blood is abnormally high; a white cell count of 10,000 or more per cubic millimeter. This is a non-specific finding. Generally when there is an increase in red cell production, the white cell count is elevated. If there are many immature red blood cells present in the circulation, the white cell count as done by a machine is elevated. A 'corrected white count' is then done manually with a microscope.
definition:
hemolysis: alteration, dissoultion, or destruction of red blood cells in such a manner that hemoglobin is liberated. The spleen normally filters the blood and removes abnormal red blood cells. If most cells are normal, the amount of hemoglobin released is easily metabolized by the liver and recycled by the body. If there are large numbers of abnormal red cells, the liver metabolizes the hemoglobin to bilirubin in quantities too great to be quickly recycled and jaundice results.
definition:
Hematuria:  Hematuria refers to the excretion of abnormal quantities of Red Blood Cells (RBCs) into the urine. ... Causes of Hematuria. ... http://www.duj.com/hematuria.html outside link
Hematuria is a clinical term referring to the presence of blood in the urine
definition:
spleen: an organ in the upper left quadrant of the abdomen that is important in immune function and in the maintenance of normal red blood cell anatomy. The spleen is the largest single immune organ in the body, playing a particularly important role in clearing some bacteria from the blood during infection. The spleen contains immune cells that activate the immune system (T cells) and produce antibodies (B cells). Red blood cells that are old or not normal in any other way are disintegrated by the spleen, releasing hemoglobin. This hemoglobin is converted to bilirubin by the liver and leads to jaundice. If the spleen is required to remove more than the usual red blood cells, it can become enlarged and increase its function, leading to increased hemolysis and jaundice.
definition:
jaundice: a yellowish staining of the skin, the whites of the eyes and deeper tissues caused by an increased presence of bilirubin (bile pigments) in the plasma of the blood. This can be a result of excessive breakdown of red blood cells or liver disease such as hepatitis (also called icterus).

Anemias caused by excessive hemolysis -outside link  

Symptoms and Signs?

Laboratory Findings  

Autoimmune Hemolytic Anemia

 

definition:
marrow: the part of the bone where the red and white cells are produced. In normal adults there is a fat in the bone marrow; in persons with anemia, the bone marrow is completely filled primarily with red blood cell precursors.
definition:
renal: relating to, involving, affecting, or located in the region of the kidneys

What does the liver do?   

Milk Thistle has been found helpful by some


Along with kidneys, the liver is also a targeted organ of 2-butoxyethanol poisoning.

definition:
pulmonary edema: abnormal accumulation of fluid in the lungs

There is also eye damage with 2-butoxyethanol, skin damage, damage to mucous membranes of sinuses, lungs, and ...

Present an abnormal blood picture showing: Erythropenia 
Present an abnormal blood picture showing: Reticulocytosis 
Present an abnormal blood picture showing: Granulocytosis 
Present an abnormal blood picture showing: Leukocytosis 
Likely to Cause Fragility of Erythrocytes 
Likely to Cause Hematuria 

Checks for this Anemia  

Are your red blood cells low functioning? 

(May not show up in number of RBCs or in the regular ways)

Posted mini version on healthboards.com  

Posted Gulf War Vets' Bulletin Board

General discussion posted February 15, 2004 

 

Posted on Gulf War Help forum

Sign up & get help if you need it

 

2-15-04

Copyright 2001 - 2009 - the present  - Margaret Hursh

THE USA recognizes that exposure to 2-butoxyethanol causes anemia * <--- link

Help to Consider LINK

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