No we have many generations chemically poisoned

 Lower levels of glutathione linked to autism
By David Liu
Apr 3, 2005, 15:11

A new study suggested that excessive cellular oxidative stress may be a factor causing autism.

In the study, researchers measured plasma glutathione and its metabolic precursors in 95 autistic children and 75 children without autism. It was found that levels of glutathione are significantly lower in autistic children than in the children without autism.

Glutathione is a key detoxifying compound in cells. The researchers believed that deficiency of glutathione cause excessive oxidative stress because the cells cannot deal with the damaging free radials adequately. The excessive free radials can damage the sensitive cells in the brain, the gastrointestinal tract, and the immune system, which eventually contribute to the development of autism.

Further studies suggested that three genes, namely, the catecho-O-methyltransferase gene, the transcobalamin II gene, and the glutathione-S-transferase M1 gene, may be affected somehow in the autistic children. It's not clear how these genes are involved in the autistic metabolic disorder. <more>
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Some have suggested this is why mercury is more of a problem for some people.

http://www.foodconsumer.org/777/8/glutathione_autism.shtml

Levels could be high or low

... and suggest exposure possible for 2-butoxyethanol

This is the chemical that can cause birth defects such as autism

Didn't we see that in the Vietnam vets' children?

This chemical should be more suspect for their harm, too than dioxin should

Why did I study 2-butoxyethanol?

 

 I have been hearing about such dangers...  Here is information for consumers:

http://www.injuryboard.com/view.cfm/Topic=1153

snip>

-Butoxyethanol is a clear colorless liquid that smells like ether. It has many names including ethylene glycol monobutyl ether, ethylene glycol butyl ether, ethylene glycol n-butyl ether, Butyl Cellusolve, butyl glycol, and butyl Oxitol. It is used as a solvent in spray lacquers, enamels, varnishes, and latex paints and as an ingredient in paint thinners and strippers, varnish removers, and herbicides. It is also used in liquid soaps, cosmetics, industrial and household cleaners, and dry-cleaning compounds.
2-Butoxyethanol acetate is a colorless liquid with a fruity odor. It is also known as ethylene glycol monobutyl ether acetate, butoxyethyl acetate, butyl glycol acetate, ethylene glycol butyl ether acetate, and acetic acid 2-butoxyethyl ester. It is used as a solvent for lacquers, varnishes, enamels, and epoxy resins. It is also used in some ink and spot remover compounds.

Exposure to 2-butoxyethanol and butoxyethanol acetate occurs mainly from breathing air or having skin contact with household products containing them. Breathing in large amounts of 2-butoxyethanol or 2-butoxyethanol acetate may result in irritation of the nose and eyes, headache, and vomiting. 2-Butoxyethanol has been found in at least 20 of the 1,430 National Priorities List sites identified by the Environmental Protection Agency (EPA).

See a doctor if you have been harmed by

Shared by liberalnurse

Evidence for linkage on chromosomes 21q and 7q in a subset of autism

Researchers of the Cincinnati Children's Hospital Medical Center found that regions of two chromosomes are linked to susceptibility for a type of autism characterized by regression in development.
Developmental regression can include the loss of previously acquired language, social skills or both.

Moreover, the study is the first to identify involvement of chromosome 21 in this type of autism.
This may explain the increased prevalence of autism spectrum disorders ( ASD ) among children with Down syndrome, who have an extra copy of chromosome 21 and are 10 times more likely to have an ASD than the general population.

The findings represent " the important first step in identifying genetic variants that may contribute to susceptibility to this specific type of ASD, " says Cindy Molloy, lead author of the study.

The study is published in the Molecular Psychiatry.

Molloy and colleagues examined a U.S. database and DNA bank of hundreds of families with autism spectrum disorders.

They identified 32 pairs of siblings, one trio of siblings and one pair of cousins who showed definite evidence of regression at the age of approximately 18 to 24 months.

Researchers confirmed previous evidence for linkage with ASD on chromosome 7 and found new evidence for susceptibility on chromosome 21 in this subset of ASD families.

The research team is now sequencing genes in those regions to find the specific genetic variant that either contributes to susceptibility or modifies the disease.

"Among children with autism or autism spectrum disorders, 20 to 30 percent have a history of regression," says Molloy. " We think this represents a genetically distinct subgroup."
Autism is a complex developmental disability that affects an individual in the areas of social interaction and communication.
Autism is a spectrum disorder that affects each individual differently and to varying degrees of severity.
As many as 1.5 million Americans - children and adults - are thought to have autism today, according to the Autism Society of America.

Source: Cincinnati Children's Hospital Medical Center, 2005

 

www.xagena.it/news/medicinenews_net_news/4bfbd52f4e8466dc12aaf30b7e057b66.html

Autism and X-fragile syndrome

Autism and X-fragile syndrome

09 Jun 2005

In the 80s, a research group at the Leioa campus of the University of the Basque Country worked on dermatoglyphs, an analysis technique applied to autistic children. Dermatoglyphs, or handprints and footprints, are useful in the morphological analysis of the symmetry of the human body.

That initial study of dermatoglyphs enabled the fluctuating asymmetry between the sides of the body to be seen, i.e. that asymmetry with a non-definable pattern being the more common amongst autistic children than in the rest of the population.

Fragile sites

Following on from this initial morphological study, the research took a cytogenetic turn. In this second phase, chromosomes of autistic children were analysed. This was undertaken with the knowledge that certain sites on the chromosomes were more prone to breaking than others. One of these fragile locations is found on the X chromosome and is known as FRAXA.

The results show that children with autism had a significantly greater frequency of expression of these fragile sites than the control population. The FRAXA fragile site expressed itself only amongst autistic children, although not in all. Thus, at a cytogenetic level, FRAXA s the most important marker for a genetic alteration that underlies autism.

Too many repetitions

Effectively, the genetic alteration on this location of the X chromosome was identified at the beginning of the 1990s. The gene known as FMR1 (Female Mental Retardation 1) is responsible for the X-fragile syndrome related to autism.

But not all autistic children showed this genetic alteration and, so, an analysis at a molecular level was undertaken in order to determine the prevalence of the X-fragile syndrome amongst individuals with mental backwardness in the Basque Country.

From a simple blood DNA analysis, it is known that the FMR1 gene has a CGG (cytosine- guanine-guanine) tri-nucleotide, usually repeated between 6 and 54 times in normal persons. On the other hand, amongst premutated persons, these repetitions appear between 55 and 200 times and, in those who have the mutated gene - i.e. those suffering from the X fragile syndrome -, they appear more than 200 times, reaching 1,000 repetitions in some cases.

The results of this analysis show that none of the individuals with the X-fragile mutation was of Basque origin though they had mental backwardness or autistic characteristics. These results led to the investigation of the stability of the FMR1 gene amongst the Basque population. The project was subsequently widened to undertake separate analyses of the different Basque regions. This study showed that there exist different mutational paths of the FMR1 gene amongst the Basque population and which may be of a relatively recent origin - thus explaining the absence of the X fragile syndrome amongst this population.

With this conclusion reached, the studies now target persons with the permutated form of the gene given that three pathologies associated with this CGG premutation have been discovered: moderate mental backwardness and autistic characteristics, premature ovarian failure before the age of 45 and ataxia - a pathology with trembling similar to that of Parkinson's. In short, there is still much to investigate regarding the X fragile syndrome.

Contact: Garazi Andonegi
garazi@elhuyar.com
34-943-363-040
Elhuyar Fundazioa
http://www.basqueresearch.com

http://www.medicalnewstoday.com/medicalnews.php?newsid=25859 

Berry interesting genetic research.

No, we have multiple generations that are chemically poisoned by a teratogen chemical

This chemical damages the X chromosome & probably others, too

So it should be suspect for ALD

Fragile X Syndrome  More Thoughts

Autism

and a whole lot more

Maybe CNS Lymphomas - that start with a horrible cough

Warnings are inadequate on this chemical whatever the product; EPA has removed it from the list of chemicals to be concerned about (due to a good job of lobbying by chemical companies). We are in a world of hurt!

With few if any restrictions now on 2-butoxyethanol & more being released into the air ... maybe this is the primary cause of men having lower sperm counts in the last 40+ years than previously

The warnings need to say what will happen to you & that the worst exposure is the vapors in one's eyes & at the cuticle areas (no pedicure/manicures for me) ... and goggles from now on, too!

By the way, Simple Green (nontoxic?) is 6% concentration of butyl cellusolve (Dow Chemical's trade name for 2-butoxyethanol) and it is used in US penitentiaries exclusively ... those guys might be worse off when they get out!

Why did I study 2-butoxyethanol?

Wonder what fishermen wash their boats with?  Some say Lysol tub 'n Tile, or Simple Green or Joy ... bet you'd find some n-butyl ethers in some of these

A 'match' for many ailments - blamed for none

I know it sounds unbelievable ... but what if I am right?

Only those harmed by it can prove this theory ... but most of the time not enough medical info is checked out. And when the blood in urine is found ... it doesn't 'match' the rest of the profile, and sometimes doctors don't even mention it to their patients.

This is the hemolysis - why the fatigue

You have to check more in the blood, however

And some of these basics

We are a chemically poisoned people

www.democraticunderground.com/discuss/duboard.php?az=show_mesg&forum=222&topic_id=1047&mesg_id=1525
2-Butoxyethanol Overview
If you or a family member has been injured, contact a personal injury attorney today. Just fill out InjuryBoard.com's on-line questionnaire and have a personal injury lawyer review your potential personal injury claim - free of charge.

2-Butoxyethanol is a clear colorless liquid that smells like ether. It has many names including ethylene glycol monobutyl ether, ethylene glycol butyl ether, ethylene glycol n-butyl ether, Butyl Cellusolve, butyl glycol, and butyl Oxitol. It is used as a solvent in spray lacquers, enamels, varnishes, and latex paints and as an ingredient in paint thinners and strippers, varnish removers, and herbicides. It is also used in liquid soaps, cosmetics, industrial and household cleaners, and dry-cleaning compounds.

2-Butoxyethanol acetate is a colorless liquid with a fruity odor. It is also known as ethylene glycol monobutyl ether acetate, butoxyethyl acetate, butyl glycol acetate, ethylene glycol butyl ether acetate, and acetic acid 2-butoxyethyl ester. It is used as a solvent for lacquers, varnishes, enamels, and epoxy resins. It is also used in some ink and spot remover compounds.

Exposure to 2-butoxyethanol and butoxyethanol acetate occurs mainly from breathing air or having skin contact with household products containing them. Breathing in large amounts of 2-butoxyethanol or 2-butoxyethanol acetate may result in irritation of the nose and eyes, headache, and vomiting. 2-Butoxyethanol has been found in at least 20 of the 1,430 National Priorities List sites identified by the Environmental Protection Agency (EPA).

See a doctor if you have been harmed by this substance. In addition, it may be important to contact an attorney who can help you protect your legal rights. Please keep in mind that there may be time limits within which you must commence suit.

Attorneys associated with InjuryBoard.com will evaluate your case free of charge. In addition, you will not pay any legal fees unless your attorney recovers money for you. Please click on the free contact an attorney button to take advantage of this valuable service.