THE CAUSES OF MCL
When one reads several of the case-histories it becomes evident that their authors wonder whether events or circumstances in their lives may have caused the disease. Since I have raised this subject on the Mantle Cell Groups mailing list the response makes it clear that many MCL patients think that way and would welcome some answer to the question, 'Why me?' The answer may be difficult to find because there are probably many possible causes.
Something triggers the t (11;14) translocation involving the immunoglobulin heavy chain gene on chromosome 14 and the bcl-1 (PRAD 1) oncogene on chromosome 1 that leads to the overexpression of Cyclin D-1. Some researchers have suggested that bacterial and viral infections may do so in some cases. Patients themselves have wondered whether environmental factors such as pollution by agrichemicals or nuclear radiation may be to blame. Others have spoken of industrial hazards in the workplace. One such is a patient who spent 40 years as an airline pilot and wondered whether the radiation he was exposed to could have been the cause. A useful line for research, that.
Studies of farmers provide some clues. Although they are generally healthier than the rest of us, farmers develop some types of cancer more often. These same tumors that are common among farmers are becoming increasingly common all over the world, according to reports from several different national cancer institutes. Besides being one of the most dangerous professions, farming includes regular contact with diesel and other engine exhausts, pesticides, solvents and paints, animal viruses and sunlight.
Could growing general population exposures to these same materials lie behind the rising incidence of these diseases globally?
Another possible category might be termed iatrogenic; radiation or chemotherapy for another cancer for example.
Mantle cell lymphoma is a distinct clinicopathologic entity characterized by expansion of the mantle area of the lymph node with neoplastic intermediate sized lymphocytes sIg, CD5, CD19, CD20, and CD22, but lacking expression of CD10 and CD23. The malignancy to arise as a result of dysregulation of the cell cycle by cyclin D1 over-expression resulting from a t(11;14) translocation. Patients typically present with advanced stage disease and pursue an aggressive clinical course. None of the available conventional chemotherapy regimens appear curative; hence, consideration of innovative treatment protocols and early bone marrow or stem cell transplantation appear warranted.
July 12, 2003 reposting of this info
If so, ask them to chart their blood history!
To have their doctors TEST for hemolytic anemia
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