Source 

Human Toxicity Excerpts RE:  butoxyethanol:

SYMPTOMATOLOGY:

• . Central nervous depression, although probably less prominent than with ethylene glycol.

• 2. No hypocalcemic tetany or metabolic acidosis with the possible exception of poisonings due to ethylene glycol monomethyl ether.

• 3. Nausea, vomiting, and sometimes diarrhea.

• 4. Prominent headache. Later abdominal and lumbar pain and costovertebral angle tenderness.

• 5. Transient polyuria & then oliguria, progressing to anuria.

• 6. Acute renal failure ...

• 7. Less critical pathological lesions may appear in brain, lung, liver, meninges and heart.

• 8. Observations in animals suggest the remote possibility of pulmonary edema, intravascular hemolysis & bone marrow depression, at least with some ether derivatives of ethylene and diethylene glycols. ... /Ethylene glycol (Group B compounds)/
  [Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984.,p. II-176]**PEER REVIEWED**

EXPOSURE ... TO HIGH CONCENTRATIONS ... OF ... VAPORS, PROBABLY IN RANGE OF 300-600 PPM FOR SEVERAL HOURS WOULD BE EXPECTED TO

CAUSE RESPIRATORY & EYE IRRITATION ...

 /Central Nervous System DEPRESSION/,

 DAMAGE TO KIDNEY

& DAMAGE TO LIVER.
[Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982. 3933]**PEER REVIEWED**

FIRST SIGN OF ORGANIC ABNORMALITY ... RESULTING FROM EXCESSIVE EXPOSURE BY ANY ROUTE LIKELY WOULD BE

ABNORMAL BLOOD PICTURE CHARACTERIZED BY

ERYTHROPENIA,

RETICULOCYTOSIS,

GRANULOCYTOSIS,

& LEUCOCYTOSIS.

SOMEWHAT MORE INTENSE EXPOSURE WOULD BE LIKELY TO CAUSE FRAGILITY OF ERYTHROCYTES & HEMATURIA.
[Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982. 3933]**PEER REVIEWED**

BONE MARROW DAMAGE. /FROM TABLE/
[Dreisbach, R.H. Handbook of Poisoning. 12th ed. Norwalk, CT: Appleton and Lange, 1987. 176]**PEER REVIEWED**

2-Butoxyethanol penetrates the skin readily, and toxic action from excessive skin exposure may be more likely than from vapor inhalation.
[American Conference of Governmental Industrial Hygienists, Inc. Documentation of the Threshold Limit Values and Biological Exposure Indices. 6th ed. Volumes I,II, III. Cincinnati, OH: ACGIH, 1991. 163]**PEER REVIEWED**

IT APPEARS THAT THIS CHEMICAL IS ONE OF THE FEW MATERIALS

TO WHICH HUMAN IS MORE RESISTANT THAN THE USUAL EXPERIMENTAL ANIMALS.

 THIS APPEARS TO BE DUE,

IN PART AT LEAST,

TO THE FACT THAT HUMANS ARE MORE RESISTANT THAN ARE MOST LAB ANIMALS TO THE HEMOLYTIC EFFECTS CAUSED BY THE MATERIAL ITSELF OR ITS METABOLITE.

(We ask, based on what?) consider ***

[Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982. 3937]**PEER REVIEWED**

... REGARDED AS MOST TOXIC GLYCOL MONOALKYL ETHER USED AS SOLVENT ... .
[Browning, E. Toxicity and Metabolism of Industrial Solvents. New York: American Elsevier, 1965. 610]**PEER REVIEWED**

THE EFFECTS /OF ALKYL DERIV OF ETHYLENE GLYCOL/ ...

UPON THE Central Nervous System 

INCLUDE HEADACHE,

DROWSINESS,

WEAKNESS,

SLURRED SPEECH,

RECRUDESCENT STUTTERING,

STAGGERING GAIT,

TREMOR,

AND BLURRED VISION.

CHANGES OF PERSONALITY ARE OFTEN NOTED ... THESE CHANGES ARE SUCH THAT THE PATIENT, IN THE ABSENCE OF AN ACCURATE OCCUPATIONAL HISTORY, MAY BE TREATED FOR SCHIZOPHRENIA OR NARCOLEPSY.

IN ACUTE POISONING WITH THE ETHYLENE GLYCOL MONOALKYL ETHERS, THERE IS ...

RENAL INJURY: ALBUMINURIA & HEMATURIA.

/ETHYLENE GLYCOL MONOALKYL ETHERS/
[Hamilton, A., and H. L. Hardy. Industrial Toxicology. 3rd ed. Acton, Mass.: Publishing Sciences Group, Inc., 1974. 301]**PEER REVIEWED**

2002