What is going on with our Immune System,?

Immunoglobulin A, B, and M what are they?

March 04, 2004

Just a quick question for all the guru's out there. My value for M was really low and highlighted in bold by the lab. The range value is 40 to 230 and mine was 29 L. Just wondering what all that means.

Headhunter25
CC

March 05, 2004

From a definition found on the internet:

quote:
Immunoglobulin A Deficiency:
Synonyms and related keywords: immunodeficiency, selective IgA deficiency, selective immunoglobulin A deficiency, primary antibody deficiencies, primary antibody deficiency, antibody deficiency, IgAD, immunodeficiency disease, sinopulmonary infection, sinus infection, otitis media, stomach cancer, Giardia lamblia, G lamblia, Helicobacter pylori, H pylori, GI cancer, gastrointestinal disease, GI disease, Crohn disease, upper respiratory tract infection, lower respiratory tract infection, chronic diarrhea, transfusion complication, blood product reaction, adverse transfusion reaction

To continue: "Secretory IgA antibodies can neutralize viruses, bind toxins, agglutinate bacteria, prevent bacteria from binding to mucosal epithelial cells, and bind to various food antigens, thus preventing their entry into the general circulation. The role of serum IgA is unclear."

"IgAD is a primary immunodeficiency disease presumed to result from a failure of terminal differentiation in IgA-positive B cells. Multipotent hematopoietic stem cells give rise to progenitors of T cells, B cells, and natural killer cells."

"The development of B-lineage cells begins in the fetal liver. B-lineage cell development then transfers to the bone marrow when it becomes the major hematopoietic organ. Pre–B cells become immature immunoglobulin M (IgM)–positive B cells and then migrate from the bone marrow to lymph node germinal centers. After leaving the bone marrow, the B cells mature and express immunoglobulin D receptors, respond to antigens, and, with the help of T cells (CD4+), undergo proliferation and plasma cell differentiation (International Union of Immunological Societies, 1999)."

Source: www.emedicine.com/med/topic1159.htm

Mother Margaret

March 05, 2004 <brownbassman100@aol.com>

I looked up some things on the internet about it. It is noted that Immunoglobulin M deficiency is very rare. Less than 0.03% of the international population. It is also fatal to infants, young children and can be in adults. Maybe that's why I get pluracy often? I get it almost every winter. I also wonder if it's because I have mycoplasma infection in my body? I can't understand why my nuero guy didn't pick up on this. My wife has been in the hospitial for surgery so I went over my med recs while waiting and saw it. Any info will be helpful.

Headhunter25
cc

March 05, 2004

In sharing your question with 'Mike' his comments are:

"The immunoglobulin molecule: That's a rather complex molecule! Well, the lymph nodes crank out this protein molecule to go after foreign bodies in an organism.

Too low numbers found in a blood test just means that particular means of defense is too low, possibly in decline.

Something is impeding the lymphs; bad nutrition, poisoning, old age, etc. Trick is to discover what caused such a condition.
I suspect you're on the path to connect that ester-alcohol solvent C6H14O2/CH3(CH2)2CH2OCH2CH2OH to lymph damage. Since the liver is definitely damaged with that substance just like longterm metalysis of ethanol, follows other organs will suffer as well."

I met Mike Simmons when he gave permission to use some of his 'pianodude' music to the website I was working on.

Then he added this www.valdezlink.com/media-ak/Exxon_Valdez_Movie.swf

Turns out he knows about various chemicals and their effects, too!
Mother Margaret

March 07, 2004 larrypam1010@sbcglobal.netcglobal.net>

Then someone explain to me Igg. Had high Igg to epstien barr 960, and high Igg to herpes 1 or 2 600+. I was told these are intibodies to the viruses. And that Igm would indicate current active infection.

Pam

March 07, 2004

Pam, is this the same thing?

quote:
IgG: Immunoglobulin G, a major class of immunoglobulins found in the blood, including many of the most common antibodies circulating in the blood. Also known as gamma globulin.

MERCK medical dictionary has some pretty good definitions, check this chapter on immune: THE MERCK MANUAL, Sec. 12, Ch. 146, Biology Of The Immune System and

THE MERCK MANUAL, Sec. 11, Ch. 145, Aids-Associated Hematologic Disorders And Malignancies

If the level is high, then your immune system is doing pretty well? You can help everyone out by checking into it and letting us know if you learn something more

Mother Margaret

March 07, 2004

Could this be an autoimmune thing going on?

If your system is out of balance, such as what I expect to be found eventually for those with hemolytic anemia from 2-butoxyethanol or diethylene glycol monobutyl ether ...

I would expect it to be diagnosed as acquired autoimmune hemolytic anemia

Mother Margaret

March 09, 2004

2-Butoxyethanol is Butyl Cellosolve (trademark of Union Carbide/Dow Chemical)
diethylene glycol monobutyl ether is Butyl Carbitol (Trademark of ")

They are both solvents, but are chemically different.

Here's a link to the MSDS, if you need help understanding MSDS or Toxicology let me know.
http://hazard.com/msds/

Just type in the product or chemical name and the search will do the rest.

My boss, a chemist, gave me the URL and will explain anything I do not understand.

Thanks
rh8x <rh8x@hotmail.com>

March 09, 2004

Great! Do you have time to look up diethylene glycol monobutyl ether?

This is all I know about it and here you note the original source showing that the Gulf War troops were exposed to it too .... I've found some synonyms, as well; they are probably the same and more.

I got a lot of help from some chemists when I first started learning about
2-butoxyethanol Seems like 2(2-buotyxethanol) would be twice as bad

C6H14O2/CH3(CH2)2CH2OCH2CH2OH
Reproductive & Fetal Effects; Liver & Kidney Damage; Blood Damage only Health Hazard level #2?

C8H18O3 / CH2(CH2)3OCH2CH2OCH2CH2OH
Kidney damage; Central Nervous System effects only Hazard level 1?

CA & EPA study

Here are products that contain them that people use regularly - Some are Not safe, wouldn't you agree? www.valdezlink.com/household112-34-5.htm
www.valdezlink.com/2_butoxyethanol_in_these.htm
(I think we are on another thread, folks)
While we're on this topic, here is a summary page I just did

Mother Margaret

fair use 3-9-04 www.gulfwarvets.com/ubb/Forum1/HTML/000153.html