Valid 05/2003 - 07/2003
Sigma-Aldrich Company Ltd.
The Old Brickyard
Gillingham, Dorset
SP8 4XT, England
Tel: 01747 822211
Emergency 24 Hour Service: 01202 733114
M A T E R I A L S A F E T Y D A T A S H E E T
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
CATALOG #: 579556
NAME: ETHYLENE GLYCOL N-BUTYL ETHER (BUTYL CELLOSOLV), 99.5+%
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
CAS #:NONE
MF: C6H14O2
EC NO: 203-905-0
SYNONYMS
BUCS * BUTOKSYETYLOWY ALKOHOL (POLISH) * 2-BUTOSSI-ETANOLO (ITALIAN) *
2-BUTOXY-AETHANOL (GERMAN) * BUTOXYETHANOL * N-BUTOXYETHANOL * 2-
BUTOXYETHANOL * 2-BUTOXY-1-ETHANOL * 2-BUTOXYETHANOL (ACGIH:OSHA) *
BUTYL CELLOSOLVE (OSHA) * BUTYLCELOSOLV (CZECH) * O-BUTYL ETHYLENE
GLYCOL * BUTYLGLYCOL (FRENCH,GERMAN) * BUTYL OXITOL * DOWANOL EB *
EKTASOLVE EB * ETHYLENE GLYCOL N-BUTYL ETHER * ETHYLENE GLYCOL,
MONOBUTYL ETHER * GAFCOL EB * GLYCOL BUTYL ETHER * GLYCOL ETHER EB *
GLYCOL MONOBUTYL ETHER * JEFFERSOL EB * MONOBUTYL ETHER OF ETHYLENE
GLYCOL * MONOBUTYL GLYCOL ETHER * 3-OXA-1-HEPTANOL * POLY-SOLV EB *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
LABEL PRECAUTIONARY STATEMENTS
TOXIC
TOXIC IN CONTACT WITH SKIN.
HARMFUL BY INHALATION AND IF SWALLOWED.
RISK OF SERIOUS DAMAGE TO EYES.
IRRITATING TO RESPIRATORY SYSTEM AND SKIN.
MAY FORM EXPLOSIVE PEROXIDES.
COMBUSTIBLE.
READILY ABSORBED THROUGH SKIN.
TARGET ORGAN(S):
BLOOD
KIDNEYS
AVOID EXPOSURE - OBTAIN SPECIAL INSTRUCTIONS BEFORE USE.
IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).
IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
WATER AND SEEK MEDICAL ADVICE.
WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE
PROTECTION.
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
CALL A PHYSICIAN IMMEDIATELY.
IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL
RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
IN CASE OF SKIN CONTACT, FLUSH WITH COPIOUS AMOUNTS OF WATER
FOR AT LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING AND
SHOES. CALL A PHYSICIAN.
IN CASE OF CONTACT WITH EYES, FLUSH WITH COPIOUS AMOUNTS OF WATER
FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY SEPARATING
THE EYELIDS WITH FINGERS. CALL A PHYSICIAN.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
EXTINGUISHING MEDIA
WATER SPRAY.
CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
SPECIAL FIREFIGHTING PROCEDURES
WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
PREVENT CONTACT WITH SKIN AND EYES.
UNUSUAL FIRE AND EXPLOSIONS HAZARDS
COMBUSTIBLE LIQUID.
EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
MAY FORM PEROXIDES OF UNKNOWN STABILITY.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
WEAR SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY
RUBBER GLOVES.
COVER WITH DRY-LIME, SAND, OR SODA ASH. PLACE IN COVERED CONTAINERS
USING NON-SPARKING TOOLS AND TRANSPORT OUTDOORS.
VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
EVACUATE AREA.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
REFER TO SECTION 8.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
USE ONLY IN A CHEMICAL FUME HOOD.
SAFETY SHOWER AND EYE BATH.
WASH CONTAMINATED CLOTHING BEFORE REUSE.
WASH THOROUGHLY AFTER HANDLING.
DO NOT BREATHE VAPOR.
AVOID CONTACT WITH EYES, SKIN AND CLOTHING.
AVOID PROLONGED OR REPEATED EXPOSURE.
NIOSH/MSHA-APPROVED RESPIRATOR.
COMPATIBLE CHEMICAL-RESISTANT GLOVES.
CHEMICAL SAFETY GOGGLES.
KEEP TIGHTLY CLOSED.
STORE IN A COOL DRY PLACE.
MOIST MATERIAL OXIDIZES EXOTHERMICALLY IN AIR REACHING IGNITION
TEMPERATURE. EXOTHERMIC REACTION WITH LITHIUM INITIATES AT 260 C AND
RAPIDLY RISES TO 960 C.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
PHYSICAL PROPERTIES
BOILING POINT: 171 C/743MM.
MELTING POINT: -75 C
FLASHPOINT 140 F
EXPLOSION LIMITS IN AIR:
UPPER 12.7 %
LOWER 1.1 %
VAPOR PRESSURE: < 1 MMHG @ 20 C
SOLUBILITY:
WATER -Z26060
MOST ORGANIC SO
MINERAL OIL
SPECIFIC GRAVITY: 0.900
FREEZING POINT: -9 C
PH: 9.5
SWISS POISON CLASS: 4
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
STABILITY
STABLE.
INCOMPATIBILITIES
STRONG OXIDIZING AGENTS
HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
CARBON MONOXIDE, CARBON DIOXIDE
HAZARDOUS POLYMERIZATION
WILL NOT OCCUR.
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
ACUTE EFFECTS
HUMAN EXPOSURE ABOVE 200 PPM CAN BE EXPECTED TO CAUSE NARCOSIS, DAMAGE
TO THE KIDNEY AND LIVER AND PRESENT AN ABNORMAL BLOOD PICTURE SHOWING
ERYTHROPENIA, RETICULOCYTOSIS, GRANULOCYTOSIS, LEUKOCYTOSIS AND WOULD
BE LIKELY TO CAUSE FRAGILITY OF ERYTHROCYTES AND HEMATURIA.
SWALLOWING OF 2-BUTOXYETHANOL RESULTS IN A SOUR TASTE THAT TURNS TO A
BURNING SENSATION AND IS FOLLOWED BY NUMBNESS OF THE TONGUE WHICH
INDICATES PARALYSIS OF THE SENSORY NERVE ENDINGS.
CAUSES CENTRAL NERVOUS SYSTEM (CNS) DEPRESSION, LOSS OF TASTE, NUMB-
NESS OF THE TONGUE, HEADACHES AND STUPOR.
NARCOTIC EFFECT
CAUSES SKIN IRRITATION.
TOXIC IF ABSORBED THROUGH SKIN.
READILY ABSORBED THROUGH SKIN.
CAUSES SEVERE EYE IRRITATION.
HARMFUL IF INHALED.
MATERIAL IS IRRITATING TO MUCOUS MEMBRANES AND UPPER
RESPIRATORY TRACT.
HARMFUL IF SWALLOWED.
LD
CHRONIC EFFECTS
TARGET ORGAN(S):
BLOOD
KIDNEYS
LIVER
CENTRAL NERVOUS SYSTEM
TESTES
OVEREXPOSURE MAY CAUSE REPRODUCTIVE DISORDER(S) BASED ON TESTS WITH
LABORATORY ANIMALS.
RTECS #: KJ8575000
ETHANOL, 2-BUTOXY-
IRRITATION DATA
SKN-RBT 500 MG OPEN MLD UCDS**
EYE-RBT 100 MG SEV AJOPAA 29,1363,1946
EYE-RBT 100 MG/24H MOD 85JCAE -,629,1986
TOXICITY DATA
ORL-RAT LD50:470 MG/KG DOWCC* MSD-46
IHL-RAT LC50:450 PPM/4H TXAPA9 68,405,1983
IPR-RAT LD50:220 MG/KG 85GMAT -,67,1982
IVN-RAT LD50:307 MG/KG AMIHAB 14,114,1956
UNR-RAT LD50:917 MG/KG GISAAA 41(11),7,1976
ORL-MUS LD50:1230 MG/KG AMIHAB 14,114,1956
IHL-MUS LC50:700 PPM/7H JIHTAB 25,157,1943
IPR-MUS LD50:536 MG/KG SCCUR* -,2,1961
IVN-MUS LD50:1130 MG/KG AMIHAB 14,114,1956
UNR-MUS LD50:1050 MG/KG GISAAA 41(11),7,1976
ORL-RBT LD50:300 MG/KG YKYUA6 32,1241,1981
SKN-RBT LD50:220 MG/KG DOWCC* MSD-46
IPR-RBT LD50:220 MG/KG 85GMAT -,67,1982
IVN-RBT LD50:252 MG/KG AMIHAB 14,114,1956
ORL-GPG LD50:1200 MG/KG JIHTAB 23,259,1941
SKN-GPG LD50:230 UL/KG TXAPA9 7,559,1965
UNR-MAM LD50:1500 MG/KG GISAAA 51(5),61,1986
TARGET ORGAN DATA
SENSE ORGANS AND SPECIAL SENSES (OTHER OLFACTION EFFECTS)
SENSE ORGANS AND SPECIAL SENSES (OTHER EYE EFFECTS)
BEHAVIORAL (GENERAL ANESTHETIC)
BEHAVIORAL (ALTERED SLEEP TIME)
BEHAVIORAL (SOMNOLENCE)
BEHAVIORAL (EXCITEMENT)
BEHAVIORAL (ATAXIA)
BEHAVIORAL (COMA)
BEHAVIORAL (ANALGESIA)
LUNGS, THORAX OR RESPIRATION (DYSPNAE)
LUNGS, THORAX OR RESPIRATION (OTHER CHANGES)
GASTROINTESTINAL (NAUSEA OR VOMITING)
GASTROINTESTINAL (OTHER CHANGES)
LIVER (TUMORS)
KIDNEY, URETER, BLADDER (HEMATURIA)
KIDNEY, URETER, BLADDER (OTHER CHANGES)
ENDOCRINE (TUMORS)
SKIN AND APPENDAGES (HAIR)
MATERNAL EFFECTS (UTERUS, CERVIX, VAGINA)
MATERNAL EFFECTS (OTHER EFFECTS ON FEMALE)
EFFECTS ON FERTILITY (PRE-IMPLANTATION MORTALITY)
EFFECTS ON FERTILITY (POST-IMPLANTATION MORTALITY)
EFFECTS ON FERTILITY (LITTER SIZE)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (MUSCULOSKELETAL SYSTEM)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (CARDIOVASCULAR SYSTEM)
NUTRITIONAL AND GROSS METABOLIC (WEIGHT LOSS OR DECREASED WEIGHT GAIN)
NUTRITIONAL AND GROSS METABOLIC (CHANGES IN: METABOLIC ACIDOSIS)
TUMORIGENIC (CARCINOGENIC BY RTECS CRITERIA)
TUMORIGENIC (EQUIVOCAL TUMORIGENIC AGENT BY RTECS CRITERIA)
ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
(RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
CONTACT A LICENSED PROFESSIONAL WASTE DISPOSAL SERVICE TO DISPOSE OF
THIS MATERIAL.
THIS COMBUSTIBLE MATERIAL MAY BE BURNED IN A CHEMICAL INCINERATOR
EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.
OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
CONTACT ALDRICH CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
EUROPEAN INFORMATION
EC INDEX NO: 603-014-00-0
TOXIC
R 20/21/22
HARMFUL BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED.
R 36/38
IRRITATING TO EYES AND SKIN.
S 36/37
WEAR SUITABLE PROTECTIVE CLOTHING AND GLOVES.
S 46
IF SWALLOWED, SEEK MEDICAL ADVICE IMMEDIATELY AND SHOW THIS
CONTAINER OR LABEL.
REVIEWS, STANDARDS, AND REGULATIONS
OEL=MAK
ACGIH TLV-TWA 20 PPM (SKIN) DTLVS* TLV/BEI,1999
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC 54,7740,1989
MSHA STANDARD-AIR:TWA 50 PPM (240 MG/M3) (SKIN)
DTLVS* 3,29,1971
OSHA PEL (GEN INDU):8H TWA 50 PPM (240 MG/M3) (SKIN)
CFRGBR 29,1910.1000,1994
OSHA PEL (CONSTRUC):8H TWA 50 PPM (240 MG/M3) (SKIN)
CFRGBR 29,1926.55,1994
OSHA PEL (SHIPYARD):8H TWA 50 PPM (240 MG/M3) (SKIN)
CFRGBR 29,1915.1000,1993
OSHA PEL (FED CONT):8H TWA 50 PPM (240 MG/M3) (SKIN)
CFRGBR 41,50-204.50,1994
OEL-AUSTRALIA: TWA 25 PPM (120 MG/M3), SKIN, JAN1993
OEL-AUSTRIA: MAK 20 PPM (100 MG/M3), SKIN, JAN1999
OEL-BELGIUM: TWA 25 PPM (121 MG/M3), SKIN, JAN1993
OEL-DENMARK: TWA 25 PPM (120 MG/M3), SKIN, JAN1999
OEL-FINLAND: TWA 25 PPM (120 MG/M3), STEL 75 PPM (350 MG/M3), SKIN,
JAN1999
OEL-FRANCE: VME 25 PPM (120 MG/M3), SKIN, JAN1999
OEL-GERMANY: MAK 20 PPM (100 MG/M3), SKIN, JAN1999
OEL-HUNGARY: TWA 100 MG/M3, STEL 200 MG/M3, SKIN, JAN1993
OEL-THE NETHERLANDS: MAC-TGG 20 PPM (100 MG/M3), STEL 40 PPM, SKIN,
JAN1999
OEL-NORWAY: TWA 20 PPM (100 MG/M3), JAN1999
OEL-THE PHILIPPINES: TWA 50 PPM (240 MG/M3), SKIN, JAN1993
OEL-POLAND: MAC(TWA) 100 MG/M3, MAC(STEL) 360 MG/M3, JAN1999
OEL-RUSSIA: STEL 5 MG/M3, JAN1993
OEL-SWEDEN: NGV 10 PPM (50 MG/M3), KTV 20 PPM (100 MG/M3), SKIN,
JAN1999
OEL-SWITZERLAND: MAK-W 20 PPM (100 MG/M3), KZG-W 40 PPM (200 MG/M3),
SKIN, JAN1999
OEL-TURKEY: TWA 50 PPM (240 MG/M3), JAN1993
OEL-UNITED KINGDOM: TWA 25 PPM (123 MG/M3), SKIN, SEP2000
OEL IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA CHECK ACGIH TLV;
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM CHECK ACGIH TLV
NIOSH REL TO ETHYLENE GLYCOL MONOBUTYL ETHER-AIR:10H TWA 5 PPM (SK)
NIOSH* DHHS #92-100,1992
NOHS 1974: HZD 29930; NIS 398; TNF 141929; NOS 199; TNE 1547951
NOES 1983: HZD 29930; NIS 402; TNF 130413; NOS 239; TNE 2139297; TFE
585932
EPA TSCA SECTION 8(B) CHEMICAL INVENTORY
EPA TSCA SECTION 8(D) UNPUBLISHED HEALTH/SAFETY STUDIES
ON EPA IRIS DATABASE
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH ANALYTICAL METHOD, 1994: ALCOHOLS IV, 1403
NIOSH ANALYTICAL METHOD, 1996: VOLATILE ORGANIC COMPOUND, 2549
NTP CARCINOGENISIS STUDIES (INHALATION):SOME EVIDENCE:MOUSE
NTPTR* NTP-TR-484,2000
NTP CARCINOGENISIS STUDIES (INHALATION):EQUIVOCAL EVIDENCE:RAT
NTPTR* NTP-TR-484,2000
NTP TOXICITY STUDIES, RPT# TOX-26, OCTOBER 2000
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
COPYRIGHT 2001 SIGMA-ALDRICH CO.
LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY
|
We
are a chemically poisoned people